HPV infection on the host immune response, include cell-mediated immunity and humoral immunity.
First, cell-mediated immunity
Human cells immunity is one of the important foundation of Genital Warts. Cell-mediated immunity is more important than the humoral immunity. With the clinical immune defect in patients with Genital Warts rash often persistent, their peripheral blood T-cell count increased inhibitory NK cell function in low, r-interferon and interleukin-2 production was reduced, while skin lesions subsided warts there is often activated T cells and NK cells infiltration, some of keratinocyte HLA-DR positive.
Immune suppression or immune defects, genital HPV infection and HPV-related diseases have increased the incidence. Genital Warts in the helper T-cell depletion, CD4/CD8 ratio inversion, its value is “1. In the Genital Warts patient’s peripheral blood and found that inhibition / cytotoxic T-cell percentage was significantly higher, auxiliary / induced T-cell ratio and ancillary / suppressor T-cell ratio were lower. CA cervix and cervical intraepithelial neoplasia (CIN) lesions in Langerhans cells decreased significantly. Genital Warts of NK cells to produce r-interferon and interleukin -2 reduced. Bowen papulosis, and anogenital cancer whose NK cells containing HPV-16 keratinocytes decreased activity of dissolve may be the disease-specific identification of target cells due to defects, cervical CA, keratinocytes did not express MHC â…¡ type antigen (HLA-DR), no such antigen-presenting function can be destructive to the immune surveillance.
Second, humoral immunity
The current serological test results showed that: â‘ the late anti-protein antibody production rate of 25% -65%, compared with the early anti-protein antibody production rate; â‘¡ detected HPV type-specific antibody seems to be no cross-reactivity; â‘¢ anti-HPV – 16E7 antibody and the presence of cervical cancer are closely related; â‘£ anti-HPV-16E4 antibody is also a place of cervical cancer, recurrent or recent sign of HPV infection; ⑤ adults and children estimated to produce the same positive rate of IgG antibodies, positive rate of different type at 10 % -75% for; â‘¥ has proved to be HPV-16 or 18 tumor antibody-positive patients, only 50% -70% can be detected in the antibody.
Third, spontaneous regression of Genital Warts
Spontaneous regression of the Genital Warts there is no systematic assessment, however, blind, placebo-controlled study found that the spontaneous regression rate of 0%, 17%, 18% and 69% for, CA dissipated or cure, there are still 45% of patients with latent infection, 67% of patients relapse.
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